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Original Papers



One-Pot Conversion of Benzyl Alcohols to N-Protected Anilines and Alkyl Alcohols to Carbamoyl Azides
Kobayashi, S.* Yamaguchi, R.; Yamamoto, F.; Komori, J.; Sakamoto, H. Kasashima, T.; Adriaenssens, L.; Lear, M. J.*
Eur. J. Org. Chem. 2023, e202300786. DOI: 10.1002/ejoc.202300786


Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of genus Hericium

Kobayashi, S.;*

Synthesis 2023, 55, 417-432. DOI: 10.1055/a-1944-9623

(This paper was selected for the cover graphic.)


Potential Degradation of 4-Methyltetrahydropyran (4-MeTHP) under Oxidation Conditions

Kobayashi, S.;* Tamura, T.

Asian J. Org. Chem. 2021, 10 (10), 2675-2681. DOI: 10.1002/ajoc.202100441

(The art of this paper was selected as a Cover Feature)




有機合成化学協会誌 2021, 79 (6), 547-557. DOI: 10.5059/yukigoseikyokaishi.79.547


Total Synthesis, Structure Revision and Neuroprotective Effect of Hericenones C–H and Their Derivatives

Kobayashi, S.;* Tamura, T.; Koshishiba, M.; Yasumoto, T.; Shimizu, S.; Kintaka, T.; Nagai, K.

J. Org. Chem. 2021, 86 (3), 2602-2620. DOI: 10.1021/acs.joc.0c02681


Stereocontrolled Total Synthesis of (+)-Isolaurenidificin and (–)-Bromlaurenidificin

Kobayashi, S.;* Hori, Y.; Yoneyama, R.; Tamura, T.; Masuyama, A.

J. Org. Chem2019, 84 (23), 15549-15556. DOI: 10.1021/acs.joc.9b02532


4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent

Kobayashi, S.;* Tamura, T.; Yoshimoto, Y.; Kawakami, T.; Masuyama, A.

Chem. Asian J. 2019, 14 (21), 3921-3937. DOI: 10.1002/asia.201901169

(This paper was selected for a special collection celebrating 100th Annual Meeting of CSJ)


Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A−C and their derivatives

Kobayashi, S.;* Hamada, Y.; Yasumoto, T.; Hashino, Y.; Masuyama, A.; Nagai, K.*

Tetrahedron Lett2018, 59 (18), 1733-1736. DOI: 10.1016/j.tetlet.2018.03.065


Syntheses of (−)-Tripterifordin and (−)-Neotripterifordin from Stevioside

Kobayashi, S.;* Shibukawa, K.; Hamada, Y.; Kuruma, T.; Kawabata, A.; Masuyama, A.

J. Org. Chem2018, 83 (3), 1606-1613. DOI: 10.1021/acs.joc.7b02916


Grignard Reactions in Cyclopentyl Methyl Ether (CPME)

Kobayashi, S.;* Shibukawa, K.; Miyaguchi, Y.; Masuyama, A.

Asian J. Org. Chem. 2016, 5 (5), 636-645. DOI: 10.1002/ajoc.201600059

(Most Accessed 07/2020 to 06/2021) 


Stereocontrolled Synthesis of a Possible Stereoisomer of Laurenidificin and a Formal Total Synthesis of (+)-Aplysiallene Featuring a Stereospecific Ring Contraction

Kobayashi, S.;* Yokoi, T.; Inoue, T.; Hori, Y.; Saka, T.; Shimomura, T.; Masuyama, A.

J. Org. Chem. 2016, 81 (4), 1484-1498. DOI: 10.1021/acs.joc.5b02595




有機合成化学協会誌 2015, 73 (2), 131-139. DOI: 10.5059/yukigoseikyokaishi.73.131


Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B and I, Hericenols B−D, and Erinacerins A and B

Kobayashi, S.;* Tamanoi, H.; Hasegawa, Y.; Segawa, Y.; Masuyama, A.

J. Org. Chem. 2014, 79 (11), 5227-5238. DOI: 10.1021/jo500795z


Evaluation of Cyclopentyl Methyl Ether (CPME) as a Solvent for Radical Reactions

Kobayashi, S.;* Kuroda, H.; Ohtsuka, Y.; Kashihara, T.; Masuyama, A.; Watanabe, K.

Tetrahedron 2013, 69 (10), 2251-2259. DOI: 10.1016/j.tet.2013.01.030


Total Synthesis and Structural Revision of Hericerin

Kobayashi, S.;* Inoue, T.; Ando, A.; Tamanoi, H.; Ryu, I.; Masuyama, A.

J. Org. Chem. 2012, 77 (13), 5819-5822. DOI: 10.1021/jo300719m


Rapid Access to 6-Bromo-5,7-dihydroxyphthalide 5-Methyl Ether by a CuBr2-Mediated Multi-Step Reaction. Concise Total Syntheses of Hericenone J and 5’-Deoxohericenone C (Hericene A)

Kobayashi, S.;* Ando, A.; Kuroda, H.; Ejima, S.; Masuyama, A.; Ryu, I.

Tetrahedron 2011, 67 (47), 9087-9092. DOI: 10.1016/j.tet.2011.09.104


Stereocontrolled Synthesis of Substituted Bicyclic Ethers through Oxy-Favorskii Rearrangement. Total Synthesis of (±)-Communiol E

Kobayashi, S.;* Kinoshita, T.; Kawamoto, T.; Wada, M.; Kuroda, H.; Masuyama, A.; Ryu, I.

J. Org. Chem. 2011, 76 (17), 7096-7103. DOI: 10.1021/jo201064h

(This article was featured in Synfacts 2011, 11, 1160.)


Black Light Induced Radical Hydroxymethylation of Alkyl Iodides with Atmospheric CO in the Presence of Tetrabutylammonium Borohydride

Kobayashi, S.; Kawamoto, T.; Uehara, S.; Fukuyama, T.; Ryu, I.*

Org. Lett. 2010, 12 (7), 1548-1551. DOI: 10.1021/ol1002847


Novel Radical Cyclization Method Accompanied by Elimination of Hydrazyl Radical

Kobayashi, S.; Hirao, H.; Kawauchi, T.; Ryu, I.*

Heterocycles 2010, 80 (2), 879-885. DOI: 10.3987/COM-09-S(S)115


Organocatalytic Enantioselective Synthesis of Nitrogen-Substituted Dihydropyran-2-one, A Key Synthetic Intermediate of 1β-Methylcarbapenems

Kobayashi, S.;* Uehara, H.; Kinoshita, T.; Sudo, T.; Ryu, I.

Org. Lett. 2009, 11 (17), 3934-3937. DOI: 10.1021/ol901544q


Enantioselective Synthesis of the Fully Functionalized ABC ring of Zoanthenol

Sugano, N.; Koizumi, Y.; Hirai, G.; Oguri, H.; Kobayashi, S.; Yamashita, S.; Hirama, M.*

Chem. Asian J. 2008, 3 (8-9), 1549-1557. DOI: 10.1002/asia.200800079


Construction of the CDE-Ring Framework of Erinacine E through Pummerer-type Cyclization

Kobayashi, S.;* Ishii, A.; Toyota, M.

Synlett 2008, (7), 1086-1090. DOI: 10.1055/s-2008-1042922


Synthesis of trans-Fused Tetrahydrooxepins: Stereoselective Allylation of Sulfur or Fluoro-substituted Tetrahydrooxepins

Kobayashi, S.;* Hori, M.; Hirama, M.

Carbohydr. Res. 2008, 343 (3), 443-452. DOI: 10.1016/j.carres.2007.11.018


Radical chain reactions using THP as a solvent

Yasuda, H.;* Uenoyama, Y.; Nobuta, O.; Kobayashi, S.; Ryu, I.*

Tetrahedron Lett. 2008, 49 (2), 367-370. DOI: 10.1016/j.tetlet.2007.11.039


Formal Total Synthesis of Neocarzinostatin Chromophore

Kobayashi, S.;* Hori, M.; Wang, G. X.; Hirama, M.*

J. Org. Chem. 2006, 71 (2), 636-644. DOI: 10.1021/jo052031o


Stereocontrolled Synthesis of the ABCDE Ring Moiety of Ciguatoxin CTX3C

Kobayashi, S.; Takahashi, Y.; Komano, K.; Alizadeh, B. H., Kawada, Y.; Oishi, T.; Tanaka, S.; Ogasawara, Y.; Sasaki, S.; Hirama, M.*

Tetrahedron 2004, 60 (38), 8375-8396. DOI: 10.1016/j.tet.2004.07.010



小林正治;* 平間正博*

有機合成化学協会誌 2004, 62 (3), 184-193. DOI: 10.5059/yukigoseikyokaishi.62.184


Synthesis of the Fully Functionalized ABCDE Ring Moiety of Ciguatoxin

Kobayashi, S.; Alizadeh, B. H.; Sasaki, S.; Oguri, H.; Hirama, M.*

Org. Lett. 2004, 6 (5), 751-754. DOI: 10.1021/ol0364475


Diastereoselective Additions of Ethynyl Grignard Reagent to Erythrulose Derivatives

Kobayashi, S.; Das, P.; Wang, G. X.; Mita, T.; Lear, M. J.; Hirama, M.*

Chem. Lett. 2002, (3), 300-301. DOI: 10.1246/cl.2002.300


The First Total Synthesis of N1999-A2: Absolute Stereochemistry and Stereochemical Implications into DNA Cleavage

Kobayashi, S.; Ashizawa, S.; Takahashi, Y.; Sugiura, Y.; Nagaoka, M.; Lear, M. J.; Hirama, M.*

J. Am Chem. Soc. 2001, 123 (45), 11294-11295. DOI: 10.1021/ja003982g


Investigation of the Total Synthesis of N1999-A2: Implication of Stereochemistry

Kobayashi, S.; Reddy, R. S.; Sugiura, Y.; Sasaki, D.; Miyagawa, N.; Hirama, M.*

J. Am Chem. Soc. 2001, 123 (12), 2887-2888. DOI: 10.1021/ja011779v


Palladium-Catalyzed Coupling of Alkenyl Iodides with Ethynyl Oxiranes: Synthesis of Epoxy Enediyne Core Intermediates Related to Neocarzinostatin Chromophore

Reddy, R. S.; Iguchi, S.; Kobayashi, S.; Hirama, M.*

Tetrahedron Lett. 1996, 37 (52), 9335-9336. DOI: 10.1016/S0040-4039(97)82957-7

Original Papers




細胞 2022, 54 (4), 226-228. ISBN: 17601-04




アグリバイオ 2021, 5 (12), 1055-1058. ISBN: 01327-11

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